Hendel is a surname, and may refer to:
- Friedrich Georg Hendel (1874–1936), Austrian high school director and entomologist mainly interested in Diptera
- Geerd Hendel (1903–1998), naval architect and native of Germany
- Nechama Hendel (1936–1998), Israeli singer
- Zvi Hendel (born 1949), a Knesset Member