Hemolytic Disease of The Newborn (anti-Kell) - Cause

Cause

Mothers who are negative for the Kell₁ antigen develop antibodies after being exposed to red blood cells that are positive for Kell₁. Over half of the cases of hemolytic disease of the newborn owing the anti-Kell antibodies are caused by multiple blood transfusions, with the remainder due to a previous pregnancy with a Kell₁ positive baby.