Nomenclature of Hematopoietic Colonies and Lineages
Between 1948 and 1950, the Committee for Clarification of the Nomenclature of Cells and Diseases of the Blood and Blood-forming Organs issued reports on the nomenclature of blood cells. An overview of the terminology is shown below, from earliest to final stage of development:
- blast
- procyte
- cyte
- metacyte
- mature cell name
The root for CFU-E is "rubri", for CFU-GM is "granulo" or "myelo" and "mono", for CFU-L is "lympho" and for CFU-Meg is "megakaryo". According to this terminology, the stages of red blood cell formation would be: rubriblast, prorubricyte, rubricyte, metarubricyte, and erythrocyte. However, the following nomenclature seems to be, at present, the most prevalent:
| Committee | "lympho" | "rubri" | "granulo" or "myelo" | "mono" | "megakaryo" |
| Lineage | Lymphoid | Myeloid | Myeloid | Myeloid | Myeloid |
| CFU | CFU-L | CFU-GEMM→CFU-E | CFU-GEMM→CFU-GM→CFU-G | CFU-GEMM→CFU-GM→CFU-M | CFU-GEMM→CFU-Meg |
| Process | lymphocytopoiesis | erythropoiesis | granulocytopoiesis | monocytopoiesis | thrombocytopoiesis |
| blast | Lymphoblast | Proerythroblast | Myeloblast | Monoblast | Megakaryoblast |
| procyte | Prolymphocyte | Polychromatophilic erythrocyte | Promyelocyte | Promonocyte | Promegakaryocyte |
| cyte | - | Normoblast | Eosino/neutro/basophilic myelocyte | Megakaryocyte | |
| metacyte | Large lymphocyte | Reticulocyte | Eosinophilic/neutrophilic/basophilic metamyelocyte, Eosinophilic/neutrophilic/basophilic band cell | Early monocyte | - |
| mature cell name | Small lymphocyte | Erythrocyte | granulocytes (Eosino/neutro/basophil) | Monocyte | thrombocytes (Platelets) |
Osteoclasts also arise from hemopoietic cells of the monocyte/neutrophil lineage, specifically CFU-GM.
Read more about this topic: Hematopoietic Stem Cell
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