A helper dependent virus also termed a gutless virus is a synthetic viral vector dependent on the assistance of a helper virus in order to replicate. Since the genome of the gutless virus does not include genes encoding the enzymes required to replicate, it is deemed safe for use in gene therapy since an infection cannot occur except in the presence of a suitable helper virus.
Famous quotes containing the words dependent and/or virus:
“For my part, I have no hesitation in saying that although the American woman never leaves her domestic sphere and is in some respects very dependent within it, nowhere does she enjoy a higher station . . . if anyone asks me what I think the chief cause of the extraordinary prosperity and growing power of this nation, I should answer that it is due to the superiority of their woman.”
—Alexis de Tocqueville (1805–1859)
“If I knew for a certainty that a man was coming to my house with the conscious design of doing me good, I should run for my life ... for fear that I should get some of his good done to me,—some of its virus mingled with my blood.”
—Henry David Thoreau (1817–1862)