Helene may refer to:
- Helene (name), a Greek feminine name
- Helen of Troy
- Helene, a figure in Greek mythology who was a friend of Aphrodite and helped her seduce Adonis.
- Helene (Amazon), a daughter of Tityrus and an Amazon who fought Achilles and died after he seriously wounded her
- Helene (moon), a moon of Saturn
- Helene, the consort of Simon Magus
- Hélène (given name), a feminine given name, the French version of Helen
- Hélène (opera), a 1904 poème lyrique or opera in one act by composer Camille Saint-Saëns
- Hélène (drama), a drame in four acts and five tableaux of 1891, with French words by Paul Delair and incidental music by André Messager
- Hélène (album), a 1989 album by Roch Voisine
- "Hélène" (song), a 1989 song by Roch Voisine