Heise may refer to:
- Bob Heise (born 1947), American Major League Baseball player
- David R. Heise (born 1937), American sociologist
- Geoff Heise, American actor
- Heinz Heise, German publishing house
- Peter Arnold Heise (1830–1879), Danish composer (Drot og marsk, "King and Marshal")
- William Heise, American film director, 1896 The Kiss
- Heise Architecture, Australian Architectural Practice