HEB may refer to:
- H-E-B, a supermarket chain in Texas and Mexico, named for founder Howard E. Butt
- Hindu Endowments Board of Singapore
- High Energy Biscuits
- HEB, the three cities of Hurst, Texas, Euless, Texas, and Bedford, Texas, all in the northeastern portion of Tarrant County, Texas
- HEB ISD (Hurst-Euless-Bedford Independent School District), the school district centered on the area
- Hot electron bolometer, a type of bolometer which functions as a photodetector
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