Heartache may refer to:
- Love sickness, condition involving romantic obsession or longing
- A broken heart or heartbreak, emotions after loss, disappointment or relationship break-up
- Heart Ache, an EP by Jesu
- Heartache (Erykah Badu album)
- Heartache (Kit Chan album)
- "Heartache", a short story by Anton Chekhov
- "Heartache", a 1987 single by Pepsi and Shirlie