Hayne is a surname, and may refer to:
- Arthur P. Hayne (1788–1867)
- Charles Seale-Hayne
- Friedrich Gottlob Hayne (1763–1832), a botanist
- Gareth Hayne
- George Hayne
- Isaac Hayne, a South Carolinian executed during the American Revolutionary War
- Jarryd Hayne, an Australian rugby league footballer
- Jason Hayne
- Kenneth Hayne, a Puisne Justice of the High Court of Australia
- Paul Hamilton Hayne
- Richard Hayne
- Robert Y. Hayne, a United States Senator from South Carolina
- Steven Hayne, a forensic pathologist from Mississippi