Free Radical Research
Ischaemic injury (injury to cells due to oxygen deprivation) is an important cause of morbidity and mortality in humans. For example, most deaths in stroke and heart attack are secondary to ischaemic injury, a consequence of the ischemic cascade. Thus, much research has been done into the causes and treatment of ischaemic injury. One important thread involves the essential role of free radicals (reactive oxygen species and the like) as modulators of ischaemic injury. This has resulted in important therapeutic advances, such as the radical-scavenging neuroprotective agent NXY-059, which was under development for the treatment of stroke.
Harry B. Demopoulos and his coworkers played a key role this research. The opening sentence of J.Cell. Mol.Med. Vol 5, No 2, 2001 pp. 163-170 Oxidative damage following cerebral ischemia depends on reperfusion D. Al. Nita, et al. states:
| “ | The concept of generation of free radicals during ischemia was first presented by Demopoulos, Flamm and co-workers... | ” |
Read more about this topic: Harry Demopoulos
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