Halperin is a variation of the Jewish surname Heilprin, and may refer to:
- Bertrand Halperin, Harvard University professor
- David A. Halperin (born 1934), American psychiatrist and expert on cults
- David M. Halperin (born 1952), American theorist in gender studies, queer theory and other fields
- Emanuel Halperin, (born 1943), Israeli media personality
- Ian Halperin, Canadian biographer
- Israel Halperin, professor at University of Toronto, Canada
- Isser Harel (born Halperin) (1912–2003), spymaster of the intelligence and the security services of Israel
- James L. Halperin (born 1952), American author and businessman
- Mark Halperin (born 1965), American political analyst for Time Magazine and Time.com and ABC News
- Maurice Halperin (1906–95), American writer, professor and diplomat
- Morton Halperin (born 1938), American expert on foreign policy and civil liberties
- Nora Gal (full name Eleonora Yakovlevna Galperina) (1912–91), Ukrainian writer and translator
- Robert Halperin (1928–85), American Olympic and Pan American Games yachting medalist, college and professional football player, one of Chicago's most-decorated World War II heroes, and Chairman of Commercial Light Co.
- Uzzi Ornan (born Uzzi'el Halperin; 1923), Israeli linguist
- Victor Halperin (1895–1983), American film director, producer, and writer
- Yonatan Ratosh (born Uriel Halperin; 1908–81), Israeli poet, leader of the Canaanite movement
- Yotam Halperin (born 1984), Israeli basketball player