Gwen may refer to:

  • Gwen (given name), including a list of people with the name
  • Gwen, or the Book of Sand, a 1985 animated film
  • Tropical Storm Gwen (disambiguation)
  • AN/URC-117 Ground Wave Emergency Network, a military command and control communications system
  • Guild Wars: Eye of the North (GW:EN), an expansion pack for a massively multiplayer online role-playing game
  • Gwen Stefani, lead singer of the ska punk band No Doubt
Fictional characters
  • Gwen Cooper, from the TV series Torchwood
  • Gwen Norbeck Munson, from the TV soap opera As the World Turns
  • Gwen Raiden, from the TV series Angel
  • Gwen Stacy, from the Marvel comics Spider-Man series
  • Gwen Tennyson, from the TV series Ben 10
  • Gwen Winthrop, from the TV soap opera Passions
  • Gwen Wu, from the animated TV series The Mighty B!
  • Gwen, from the American Girl doll collection
  • Gwen, from the MMORPG Guild Wars, including Eye of the North
  • Gwen, from the American animated series Mission Hill
  • Gwen, from the animated TV series Total Drama Island
  • Gwen Grayson, from the 2005 film Sky High
  • Gwen West, from the TV sitcom Gavin & Stacey
  • Gwen Meighen, an air stewardess from the 1968 novel Airport
    • The same character in the 1970 film adaptation, Airport