The following table shows the principal casts of the major productions of Guys and Dolls:
| Nathan Detroit | Miss Adelaide | Sky Masterson | Sister Sarah Brown | Nicely-Nicely Johnson | Arvide Abernathy | Big Jule | Harry the Horse | Benny Southstreet | |
|---|---|---|---|---|---|---|---|---|---|
| Original Broadway Production | Sam Levene | Vivian Blaine | Robert Alda | Isabel Bigley | Stubby Kaye | Pat Rooney | B.S. Pully | Tom Pedi | Johnny Silver |
| Original London Production | Sam Levene | Vivian Blaine | Jerry Wayne | Lizbeth Webb | Stubby Kaye | Ernest Butcher | Lew Herbert | Tom Pedi | Johnny Silver |
| 1955 Film | Frank Sinatra | Vivian Blaine | Marlon Brando | Jean Simmons | Stubby Kaye | Regis Toomey | B.S. Pully | Sheldon Leonard | Johnny Silver |
| 1976 Broadway Revival | Robert Guillaume | Norma Donaldson | James Randolph | Ernestine Jackson | Ken Page | Emett “Babe” Wallace | Walter White | John Russell | Christophe Pierre |
| 1982 London Revival | Bob Hoskins | Julia McKenzie | Ian Charleson | Julie Covington | David Healy | John Normington | Jim Carter | Bill Paterson | Barrie Rutter |
| 1992 Broadway Revival | Nathan Lane | Faith Prince | Peter Gallagher | Josie de Guzman | Walter Bobbie | John Carpenter | Herschel Sparber | Ernie Sabella | J.K. Simmons |
| 2005 London Revival | Douglas Hodge | Jane Krakowski | Ewan McGregor | Jenna Russell | Martyn Ellis | Niall Buggy | Sevan Stephan | Norman Bowman | Cory English |
| 2008 Melbourne Production | Garry McDonald | Marina Prior | Ian Stenlake | Lisa McCune | Shane Jacobson | Russell Newman | Magda Szubanski | Adam Murphy | Wayne Scott Kermond |
| 2009 Broadway Revival | Oliver Platt | Lauren Graham | Craig Bierko | Kate Jennings Grant | Tituss Burgess | Jim Ortlieb | Glenn Fleshler | Jim Walton | Steve Rosen |
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