The Guianan White-eared Opossum, Didelphis imperfecta, is an opossum species from South America. It is found in Brazil, Suriname, French Guiana and Venezuela.
This species, together with the Andean White-eared Opossum (D. pernigra), was separated from the White-eared Opossum (D. albiventris) in 2002, having been included with that species in 1993.