Guajira may refer to:
- Department of La Guajira, a department of Colombia which includes most of the Guajira Peninsula
- La Guajira Desert, a desert which covers most of the Guajira Peninsula
- Guajira Peninsula, a peninsula in the northernmost part of South America shared by Colombia and Venezuela
- Guajiro People, (Wayuu) a South American ethnic group inhabiting northeastern Colombia and northwestern Venezuela
- Guajira (Cuban slang), a Spanish-language demonym signifying a female from the Cuban countryside (guajiro: male)
- Guajira (music), a style of Cuban music, song or dance
- Guajira, Colombian telenovela