First Generation Catalyst
The first well-defined ruthenium catalyst for olefin metathesis was discovered in 1992. It was prepared from RuCl2(PPh3)4 and diphenylcyclopropene.
This initial ruthenium catalyst was followed in 1995 by what is now known as the first generation Grubbs catalyst. It is easily synthesized from RuCl2(PPh3)3, phenyldiazomethane, and tricyclohexylphosphine in a one-pot synthesis.
The first generation Grubbs catalyst, while largely replaced by the second generation catalyst in usage, was not only the first catalyst to be developed other than those developed by Richard R. Schrock (Schrock carbenes), but is also important as a precursor to all other Grubbs-type catalysts.
Read more about this topic: Grubbs' Catalyst
Famous quotes containing the word generation:
“... there are some who, believing that all is for the best in the best of possible worlds, and that to-morrow is necessarily better than to-day, may think that if culture is a good thing we shall infallibly be found to have more of it that we had a generation since; and that if we can be shown not to have more of it, it can be shown not to be worth seeking.”
—Katharine Fullerton Gerould (1879–1944)