Greyfriars may refer to:
- the Franciscan Order of Friars Minor, in particular the Conventual Franciscans
- Greyfriars, Canterbury, earliest English Franciscan friary
- Greyfriars, Coventry, former monastic house
- Greyfriars Kirk, Edinburgh, a church
- Greyfriars Bobby, a renowned dog in Edinburgh
- Greyfriars Kirkyard, a graveyard in Edinburgh
- Greyfriars, Oxford, a former Permanent Private Hall of the University of Oxford
- Greyfriars, Preston, an electoral ward in Lancashire
- Greyfriars School, in fiction
- Greyfriars, Leicester, burial place of Richard III
- Greyfriars, London, a former friary
- Christ Church Greyfriars, in London
- Greyfriars, Gloucester, the ruins of a monastery, also a street named after the same
- Greyfriars, Bristol, a former monastic house.