History
In medical literature, Robert James Graves, in 1835, was the first to describe the association of a thyroid goitre with exophthalmos of the eye. Graves' ophthalmopathy may occur before, with, or after the onset of overt thyroid disease and usually has a slow onset over many months.
Read more about this topic: Graves' Ophthalmopathy
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—Edgar Allan Poe (1809–1849)