Grapefruit Seed Extract - Precautions

Precautions

Grapefruit can have a number of interactions with certain drugs, increasing the potency of many compounds, including warfarin (coumadin). Grapefruit has components that inhibit the CYP3A4 enzyme in the intestine. Thus, it is this effect that increases the rate of absorption of several drugs. There are concerns about the safety of ingesting synthetic preservatives found in grapefruit seed extract.

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