History
A pharmacological study in 1989 evaluated the possibility of interaction between ethanol ingestion and medication with the dihydropyridine calcium channel blocker - felodipine. Grapefruit juice was used as a flavouring additive to mask the taste of alcohol during the study. The study showed an increase in felodipine concentrations compared to results obtained in other investigations of the drug, and patients who were given the alcohol and grapefruit juice registered lower blood pressure and more adverse effects compared to the group of subjects on felodipine alone. Further investigations revealed that grapefruit juice strikingly elevated felodipine bioavailability and could influence its other pharmacokinetic and pharmacodynamic properties.
Read more about this topic: Grapefruit Drug Interactions
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—Walter Bagehot (1826–1877)
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