Research
A recent randomized, double-blind, placebo-controlled crossover trial with 50 adults with coronary disease or ≥1 cardiac risk factors treated with muscadine grape seed supplementation concluded that: "Four weeks of muscadine grape seed supplementation in subjects with increased cardiovascular risk did not produce a statistically significant increase in brachial flow-mediated vasodilation or a significant change in other biomarkers of inflammation, lipid peroxidation, or antioxidant capacity. However, the muscadine grape seed supplement did result in a significant increase in resting brachial diameter. The clinical significance of the effect on resting diameter is not yet established."
However, a 2011 meta-analysis of randomized controlled trials, concluded that "grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or C-reactive protein levels."
The US National Center for Complementary and Alternative Medicine (NCCAM) reported that oral administration of grape seed extract was well tolerated in people over 8 weeks of a clinical trial. In one completed clinical trial, grape seed extract did not alleviate the hardening of breast tissue in female patients undergoing radiation therapy to treat breast cancer.
A 2012 laboratory study showed that grape seed extract killed head and neck cancer cells while leaving healthy cells unharmed.
Read more about this topic: Grape Seed Extract
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