Granulocyte Macrophage Colony-stimulating Factor
| Gene Ontology | |
|---|---|
| Molecular function | • cytokine activity • granulocyte macrophage colony-stimulating factor receptor binding • protein binding • growth factor activity |
| Cellular component | • extracellular region • extracellular space |
| Biological process | • embryonic placenta development • immune response • positive regulation of cell proliferation • positive regulation of gene expression • positive regulation of macrophage derived foam cell differentiation • positive regulation of interleukin-23 production • epithelial fluid transport • positive regulation of tyrosine phosphorylation of Stat5 protein • myeloid dendritic cell differentiation • negative regulation of apoptotic process • positive regulation of DNA replication • positive regulation of survival gene product expression • negative regulation of cytolysis • positive regulation of podosome assembly • dendritic cell differentiation |
| Sources: Amigo / QuickGO | |
131.41 – 131.41 Mb
54.25 – 54.25 Mb
| Granulocyte-macrophage colony-stimulating factor | |||||||||||||||||||||||||||||||||||||
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| three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor | |||||||||||||||||||||||||||||||||||||
| Identifiers | |||||||||||||||||||||||||||||||||||||
| Symbol | GM_CSF | ||||||||||||||||||||||||||||||||||||
| Pfam | PF01109 | ||||||||||||||||||||||||||||||||||||
| Pfam clan | CL0053 | ||||||||||||||||||||||||||||||||||||
| InterPro | IPR000773 | ||||||||||||||||||||||||||||||||||||
| PROSITE | PDOC00584 | ||||||||||||||||||||||||||||||||||||
| SCOP | 2gmf | ||||||||||||||||||||||||||||||||||||
| SUPERFAMILY | 2gmf | ||||||||||||||||||||||||||||||||||||
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. Read more about Granulocyte Macrophage Colony-stimulating Factor: Functions, Genetics, Glycosylation, Clinical Significance Famous quotes containing the word factor:“Children of the middle years do not do their learning unaffected by attendant feelings of interest, boredom, success, failure, chagrin, joy, humiliation, pleasure, distress and delight. They are whole children responding in a total way, and what they feel is a constant factor that can be constructive or destructive in any learning situation.” | |||||||||||||||||||||||||||||||||||||