Granulocyte Macrophage Colony-stimulating Factor

Granulocyte Macrophage Colony-stimulating Factor

Identifiers Symbols CSF2; GMCSF External IDs OMIM: 138960 MGI: 1339752 HomoloGene: 600 GeneCards: CSF2 Gene

Gene Ontology
Molecular function • cytokine activity
• granulocyte macrophage colony-stimulating factor receptor binding
• protein binding
• growth factor activity
Cellular component • extracellular region
• extracellular space
Biological process • embryonic placenta development
• immune response
• positive regulation of cell proliferation
• positive regulation of gene expression
• positive regulation of macrophage derived foam cell differentiation
• positive regulation of interleukin-23 production
• epithelial fluid transport
• positive regulation of tyrosine phosphorylation of Stat5 protein
• myeloid dendritic cell differentiation
• negative regulation of apoptotic process
• positive regulation of DNA replication
• positive regulation of survival gene product expression
• negative regulation of cytolysis
• positive regulation of podosome assembly
• dendritic cell differentiation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1437 12981 Ensembl ENSG00000164400 ENSMUSG00000018916 UniProt P04141 P01587 RefSeq (mRNA) NM_000758.3 NM_009969.4 RefSeq (protein) NP_000749.2 NP_034099.2 Location (UCSC) Chr 5:
131.41 – 131.41 Mb Chr 11:
54.25 – 54.25 Mb PubMed search
Granulocyte-macrophage colony-stimulating factor
three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor
Identifiers
Symbol GM_CSF
Pfam PF01109
Pfam clan CL0053
InterPro IPR000773
PROSITE PDOC00584
SCOP 2gmf
SUPERFAMILY 2gmf
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
Granulocyte macrophage colony-stimulating factor
Systematic (IUPAC) name
Human granulocyte macrophage colony stimulating factor
Clinical data
Pregnancy cat. ?
Legal status ?
Identifiers
CAS number 83869-56-1 Y
ATC code L03AA09
DrugBank DB00020
Chemical data
Formula C639H1006N168O196S8
Mol. mass 14434.5 g/mol
N (what is this?) (verify)

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts.

Read more about Granulocyte Macrophage Colony-stimulating Factor:  Functions, Genetics, Glycosylation, Clinical Significance

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