Granulocyte Macrophage Colony-stimulating Factor
| Gene Ontology | |
|---|---|
| Molecular function | • cytokine activity • granulocyte macrophage colony-stimulating factor receptor binding • protein binding • growth factor activity |
| Cellular component | • extracellular region • extracellular space |
| Biological process | • embryonic placenta development • immune response • positive regulation of cell proliferation • positive regulation of gene expression • positive regulation of macrophage derived foam cell differentiation • positive regulation of interleukin-23 production • epithelial fluid transport • positive regulation of tyrosine phosphorylation of Stat5 protein • myeloid dendritic cell differentiation • negative regulation of apoptotic process • positive regulation of DNA replication • positive regulation of survival gene product expression • negative regulation of cytolysis • positive regulation of podosome assembly • dendritic cell differentiation |
| Sources: Amigo / QuickGO | |
131.41 – 131.41 Mb
54.25 – 54.25 Mb
| Granulocyte-macrophage colony-stimulating factor | |||||||||||||||||||||||||||||||||||||
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| three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor | |||||||||||||||||||||||||||||||||||||
| Identifiers | |||||||||||||||||||||||||||||||||||||
| Symbol | GM_CSF | ||||||||||||||||||||||||||||||||||||
| Pfam | PF01109 | ||||||||||||||||||||||||||||||||||||
| Pfam clan | CL0053 | ||||||||||||||||||||||||||||||||||||
| InterPro | IPR000773 | ||||||||||||||||||||||||||||||||||||
| PROSITE | PDOC00584 | ||||||||||||||||||||||||||||||||||||
| SCOP | 2gmf | ||||||||||||||||||||||||||||||||||||
| SUPERFAMILY | 2gmf | ||||||||||||||||||||||||||||||||||||
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. Read more about Granulocyte Macrophage Colony-stimulating Factor: Functions, Genetics, Glycosylation, Clinical Significance Famous quotes containing the word factor:“In his very rejection of art Walt Whitman is an artist. He tried to produce a certain effect by certain means and he succeeded.... He stands apart, and the chief value of his work is in its prophecy, not in its performance. He has begun a prelude to larger themes. He is the herald to a new era. As a man he is the precursor of a fresh type. He is a factor in the heroic and spiritual evolution of the human being. If Poetry has passed him by, Philosophy will take note of him.” | |||||||||||||||||||||||||||||||||||||