Gonadotropin-releasing Hormone Agonist - Agonists With Double and Single Substitutions

Agonists With Double and Single Substitutions

GnRH agonists are synthetically modeled after the natural GnRH decapeptide with specific amino acid substitutions typically in position 6 and 10. These substitutions inhibit rapid degradation. Agonists with 2 substitutions include:

  1. leuprolide (Lupron, Eligard)
  2. buserelin (Suprefact, Suprecor)
  3. nafarelin (Synarel) (only a single substitution at position 6)
  4. histrelin (Supprelin LA, Vantas)
  5. goserelin (Zoladex)
  6. deslorelin (Suprelorin, Ovuplant)

Triptorelin is an agonist with only a single substitution at position 6. In India,Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA".

  • Leuprolide

  • Buserelin

  • Nafarelin

  • Histrelin

  • Goserelin

  • Deslorelin

Read more about this topic:  Gonadotropin-releasing Hormone Agonist

Famous quotes containing the words double and/or single:

    “You know, when these New Negroes have their convention—that is going to be the chairman of the Committee on Unending Agitation. Race, race, race!... Damn, even the N double A C P takes a holiday sometimes!”
    —Lorraine Hansberry (1930–1965)

    “A continual feast of commendation is only to be obtained by merit or by wealth: many are therefore obliged to content themselves with single morsels, and recompense the infrequency of their enjoyment by excess and riot, whenever fortune sets the banquet before them.”
    —Samuel Johnson (1709–1784)