Gomez's fifth studio record, How We Operate was released on 2 May 2006. It was the first record the band did not produce themselves, letting Gil Norton (Foo Fighters, Pixies) take the reins. The record was developed in the band's Studio and later recorded in 6 weeks at RAK Studios, London.
The album's title track was featured in the Grey's Anatomy episode "Deterioration of the Fight or Flight Response", and later covered by Kevin McKidd in the season seven episode "Song Beneath the Song". On 14 February 2006 their song "Get Miles" was featured in the House episode "Distractions", and on 6 March 2007, their song "See the World" was featured in the House episode "Half-Wit". "See the World" was also featured in the "Bones" episode "Widow's Son In the Windshield".
They were also one of the many bands featured on a John Lennon Tribute aired on BBC Radio2 to mark the 25th anniversary of the musician's death. Gomez performed "Hey Bulldog" by The Beatles, and "Instant Karma!" by Lennon.
"How We Operate" is also the ending song to the 2007 remake of the horror film The Hitcher, and acts as the title music for the pilot episode of The Riches.
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