2000s
- 2000 Madonna – The Next Best Thing
- Kim Basinger – Bless the Child / I Dreamed of Africa
- Melanie Griffith – Cecil B. DeMented
- Bette Midler – Isn't She Great
- Demi Moore – Passion of Mind
- 2001 Mariah Carey – Glitter
- Penélope Cruz – Blow / Captain Corelli's Mandolin / Vanilla Sky
- Angelina Jolie – Lara Croft: Tomb Raider / Original Sin
- Jennifer Lopez – Angel Eyes / The Wedding Planner
- Charlize Theron – Sweet November
- 2002 Madonna – Swept Away & Britney Spears – Crossroads (tie)
- Angelina Jolie – Life or Something Like It
- Jennifer Lopez – Enough / Maid in Manhattan
- Winona Ryder – Mr. Deeds
- 2003 Jennifer Lopez – Gigli
- Drew Barrymore – Charlie's Angels: Full Throttle / Duplex
- Kelly Clarkson – From Justin to Kelly
- Cameron Diaz – Charlie's Angels: Full Throttle
- Angelina Jolie – Beyond Borders / Lara Croft Tomb Raider: The Cradle of Life
- 2004 Halle Berry – Catwoman (award accepted in person)
- Hilary Duff – A Cinderella Story / Raise Your Voice
- Angelina Jolie – Alexander / Taking Lives
- Mary-Kate and Ashley Olsen – New York Minute
- Shawn & Marlon Wayans (The Wayans "Sisters") – White Chicks
- 2005 Jenny McCarthy – Dirty Love
- Jessica Alba – Fantastic Four / Into the Blue
- Hilary Duff – Cheaper by the Dozen 2 / The Perfect Man
- Jennifer Lopez – Monster-in-Law
- Tara Reid – Alone in the Dark
- 2006 Sharon Stone – Basic Instinct 2
- Hilary Duff and Haylie Duff – Material Girls
- Lindsay Lohan – Just My Luck
- Kristanna Loken – BloodRayne
- Jessica Simpson – Employee of the Month
- 2007 Lindsay Lohan – I Know Who Killed Me as Aubrey Fleming & Lindsay Lohan – I Know Who Killed Me as Dakota Moss (tie)
- Jessica Alba – Awake / Fantastic Four: Rise of the Silver Surfer / Good Luck Chuck
- Logan Browning, Janel Parrish, Nathalia Ramos and Skyler Shaye – Bratz: The Movie
- Elisha Cuthbert – Captivity
- Diane Keaton – Because I Said So
- 2008 Paris Hilton – The Hottie and the Nottie
- Jessica Alba – The Eye / The Love Guru
- Annette Bening, Eva Mendes, Debra Messing, Jada Pinkett Smith and Meg Ryan – The Women
- Cameron Diaz – What Happens in Vegas
- Kate Hudson – Fool's Gold / My Best Friend's Girl
- 2009 Sandra Bullock – All About Steve (award accepted in person)
- Beyoncé – Obsessed
- Miley Cyrus – Hannah Montana: The Movie
- Megan Fox – Jennifer's Body / Transformers: Revenge of the Fallen
- Sarah Jessica Parker – Did You Hear About the Morgans?
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