Golden Hamsters in Scientific Research
Hamsters are widely used in research. For example, according to the Canadian Council for Animal Care, a total of 6,402 hamsters were used for research in 2006 in Canada, making them the fourth most popular rodent after mice (910,540), rats (331,560), and gerbils (37,246).
In captivity, golden hamsters follow well-defined daily routines of wheel-running activity, which has made them popular subjects in circadian rhythms research. They have a number of fixed action patterns that are readily observed, including scent-marking and body grooming, which is of interest in ethology (the study of animal behaviour).
By far, though, the greatest use of hamsters is in biomedical research. Among other things, because captive golden hamsters are highly inbred (being descended from only a few captured individuals), they have a high incidence of a genetic heart condition causing dilated cardiomyopathy. Several inbred strains of hamsters have been developed as animal models for human forms of dilated cardiomyopathy. The gene responsible for hamster cardiomyopathy in a widely studied inbred hamster strain, BIO14.6, has been identified as being delta-sarcoglycan. Pet hamsters are also potentially prone to cardiomyopathy, which is a not infrequent cause of unexpected sudden death in adolescent or young adult hamsters.
Syrian hamsters are also widely-used in research into alcoholism, by virtue of their large livers, and ability to metabolise high doses.
Scientific studies of animal welfare concerning captive golden hamsters have shown they prefer to use running wheels of large diameters (35 cm diameter was preferred over 23 cm, and 23 cm over 17.5 cm,), and that they prefer bedding material which allows them to build nests, if nesting material is not already available. They prefer lived-in bedding (up to two weeks old - longer durations were not tested) over new bedding, suggesting they may prefer bedding changes at two-week intervals rather than weekly or daily. They also prefer opaque tubes closed at one end, 15 cm in diameter, to use as shelter in which to nest and sleep.
The golden hamster can contract contagious reticulum cell sarcoma which can be transmitted from one golden hamster to another by means of the bite of the mosquito Aedes aegypti.
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