Flare Effect and Downregulation
Agonists do not quickly dissociate from the GnRH receptor. As a result initially there is an increase in FSH and LH secretion (so-called "flare effect").
However after about ten days a profound hypogonadal effect (i.e. decrease in FSH and LH) is achieved through receptor downregulation by internalization of receptors. Generally this induced and reversible hypogonadism is the therapeutic goal.
Read more about this topic: Gn RH Agonists
Famous quotes containing the words flare and/or effect:
“still I’m ready to believe perhaps
some lives
tremble and flare up there, four blocks away ...”
—Denise Levertov (b. 1923)
“The effect of having other interests beyond those domestic works well. The more one does and sees and feels, the more one is able to do, and the more genuine may be one’s appreciation of fundamental things like home, and love, and understanding companionship.”
—Amelia Earhart (1897–1937)