Species Distribution
Mice genetically engineered to lack glutathione peroxidase 1 (Gpx1 knockout mice) are grossly phenotypically normal and have normal lifespans, indicating this enzyme is not critical for life. However, Gpx1 -/- mice develop cataracts at an early age and exhibit defects in muscle satellite cell proliferation.
However, glutathione peroxidase 4 knockout mice die during early embryonic development.
Some evidence, though, indicates reduced levels of glutathione peroxidase 4 can increase life expectancy in mice.
No information is available on knockouts of the other isozymes.
The bovine erythrocyte enzyme has a molecular weight of 84 kDa.
Read more about this topic: Glutathione Peroxidase
Famous quotes containing the words species and/or distribution:
“Any reading not of a vicious species must be a good substitute for the amusements too apt to fill up the leisure of the labouring classes.”
—James Madison (1751–1836)
“The question for the country now is how to secure a more equal distribution of property among the people. There can be no republican institutions with vast masses of property permanently in a few hands, and large masses of voters without property.... Let no man get by inheritance, or by will, more than will produce at four per cent interest an income ... of fifteen thousand dollars] per year, or an estate of five hundred thousand dollars.”
—Rutherford Birchard Hayes (1822–1893)