Glucose Transporter - Glucose Transport in Yeast

Glucose Transport in Yeast

In Saccharomyces cerevisiae glucose transport takes place through facilitated diffusion. The transport proteins are mainly from the Hxt family, but many other transporters have been identified.

Name Properties Notes
Snf3 low-glucose sensor; repressed by glucose; low expression level; repressor of Hxt6
Rgt2 high-glucose sensor; low expression level
Hxt1 Km: 100 mM, 129 - 107 mM low-affinity glucose transporter; induced by high glucose level
Hxt2 Km = 1.5 - 10 mM high/intermediate-affinityglucose transporter; induced by low glucose level
Hxt3 Vm = 18.5, Kd = 0.078, Km = 28.6/34.2 - 60 mM low-affinity glucose transporter
Hxt4 Vm = 12.0, Kd = 0.049, Km = 6.2 intermediate-affinity glucose transporter
Hxt5 Km = 10 mM Moderate glucose affinity. Abundant during stationary phase, sporulation and low glucose conditions. Transcription repressed by glucose.
Hxt6 Vm = 11.4, Kd = 0.029, Km = 0.9/14, 1.5 mM high glucose affinity
Hxt7 Vm = 11.7, Kd = 0.039, Km = 1.3, 1.9, 1.5 mM high glucose affinity
Hxt8 low expression level
Hxt9 involved in pleiotropic drug resistance
Hxt11 involved in pleiotropic drug resistance
Gal2 Vm = 17.5, Kd = 0.043, Km = 1.5, 1.6 high galactose affinity

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