Gliese may refer to:
- Rochus Gliese (1891—1978), a German actor, director, production designer, and art director
- Wilhelm Gliese (1915–1993), a German astronomer, best known for the Gliese Catalogue of Nearby Stars
- Gliese Catalogue of Nearby Stars, a modern star catalog of stars located within 25 parsecs of the Earth
- Gliese 581, a red dwarf star orbited by several extra-solar planets, at least one of which is in the star's habitable zone
- Gliese 667, a triple star system in the constellation of Scorpius containing exoplanet GJ 667 Cc in one of the stars' habitable zone