The Gewald reaction is an organic reaction involving the condensation of a ketone (or aldehyde when R2 = H) with a α-cyanoester in the presence of elemental sulfur and base to give a poly-substituted 2-amino-thiophene.
The reaction is named after the German chemist Karl Gewald (born 1930).
Read more about Gewald Reaction: Reaction Mechanism, Variations
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“The excessive increase of anything often causes a reaction in the opposite direction.”
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