George Patterson may refer to:
- George Patterson (advertiser), Australian advertising pioneer
- George Patterson (baseball), outfielder during the 1884 Philadelphia Keystones season
- George Patterson (basketball), basketball player
- George Patterson (cricketer), Philadelphian cricketer
- George Patterson (football), football (soccer) manager
- George Patterson (ice hockey), ice hockey player
- George Patterson (missionary), Scottish missionary doctor
- George Robert Patterson (1863–1906), United States Representative from Pennsylvania
- George Sutton Patterson, Canadian representative on UNTCOK
- George Washington Patterson, United States Representative from New York
- George W. Patterson (Oregon politician), state senator from Oregon
- George Patterson Y&R, an Australasian advertising agency
- George Patterson, founder of Georgian Wicca