George Johnston may refer to:
- George Johnston (naturalist) (1797–1855), Scottish naturalist and physician
- George Johnston (New South Wales) (1764–1823), Lieutenant-Governor of New South Wales
- George Johnston (novelist) (1912–1970), Australian journalist and novelist
- George Johnston (politician) (1884–1977), Canadian politician
- George Johnston (general) (1868-1949), Australian army general and politician
- George Johnston (engineer) (1855–1945), Scottish engineer and motorcar designer
- George Johnston (ice hockey) (1920-2006), National Hockey League player
- George Johnston (footballer) (b. 1947), Scottish footballer
- George Benson Johnston (1913–2004), Canadian poet.
- George Doherty Johnston (1832–1910), American General and politician