Gene Regulatory Network - Network Connectivity

Network Connectivity

Empirical data indicate that biological gene networks are sparsely connected, and that the average number of upstream-regulators per gene is less than two. Theoretical results show that selection for robust gene networks will favor minimally complex, more sparsely connected, networks. These results suggest that a sparse, minimally connected, genetic architecture may be a fundamental design constraint shaping the evolution of gene network complexity.

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Famous quotes containing the word network:

    A culture may be conceived as a network of beliefs and purposes in which any string in the net pulls and is pulled by the others, thus perpetually changing the configuration of the whole. If the cultural element called morals takes on a new shape, we must ask what other strings have pulled it out of line. It cannot be one solitary string, nor even the strings nearby, for the network is three-dimensional at least.
    Jacques Barzun (b. 1907)