Geffen (Hebrew: גֶּפֶן, lit. Grapevine) is a Hebrew surname, and may refer to:
- Aviv Geffen (born 1973), Israeli rock singer
- David Geffen (born 1943), American record executive, film producer and theatrical producer
- Maxwell M Geffen (1896-1980), American editor and publisher from New York
- Tobias Geffen (1870-1970), rabbi from Atlanta, Georgia
- Yehonatan Geffen (born 1947), Israeli writer
Geffen may also refer to:
- Gefen, a moshav in central Israel
- Gefen Publishing House, an English language publishing firm located in Jerusalem, Israel
- The Geffen Film Company, a motion picture distributor and production company founded by David Geffen
- Geffen Records, a record label founded by David Geffen
- Geffen Playhouse, a theater in Los Angeles, California, named after David Geffen
- Geffen, Netherlands, a town in the Dutch municipality of Maasdonk
- Geffen (Ragnarok Online), a town in the fantasy world of Ragnarok Online