Function
GATA-3 belongs to the GATA family of transcription factors. GATA-3 regulates luminal epithelial cell differentiation in the mammary gland. The protein contains two GATA-type zinc fingers and is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells. It is hypothesised that GATA-3 may play tissue specific roles.
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