Gassman Indole Synthesis
The Gassman indole synthesis is a series of chemical reactions used to synthesize substituted indoles from aniline.
This is a one-pot chemical reaction, and none of the intermediates are isolated. R1 can be hydrogen or alkyl, while R2 works best with aryl, but can also be alkyl. Electron-rich anilines, such as 4-methoxyaniline, tend to fail in this reaction.
The 3-position thiomethyl group is often removed using Raney nickel to give the 3-H-indole.
Read more about Gassman Indole Synthesis: Reaction Mechanism
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