Source of Eicosanoids
From GLA, the body forms dihomo-γ-linolenic acid (DGLA). This is one of the body's three sources of eicosanoids (along with AA and EPA.) DGLA is the precursor of the prostaglandin PGH1, which in turn forms PGE1 and the thromboxane TXA1. PGE1 has a role in regulation of immune system function and is used as the medicine alprostadil. TXA1 modulates the pro-inflammatory properties of the thromboxane TXA2.
Unlike AA and EPA, DGLA cannot yield leukotrienes. However it can inhibit the formation of pro-inflammatory leukotrienes from AA.
Although GLA is an n−6 fatty acid, a type of acid that is, in general, pro-inflammatory, it has anti-inflammatory properties. (See discussion at Essential fatty acid interactions: The paradox of dietary GLA.)
Read more about this topic: gamma-Linolenic Acid
Famous quotes containing the words source of and/or source:
“As soon as man began considering himself the source of the highest meaning in the world and the measure of everything, the world began to lose its human dimension, and man began to lose control of it.”
—Václav Havel (b. 1936)
“The ungentlemanly expressions and gasconading conduct of yours relative to me yesterday was in true character of yourself and unmask you to the world and plainly show that they were ebullitions of a base mind ... and flow from a source devoid of every refined sentiment or delicate sensations.”
—Andrew Jackson (1767–1845)