Functions
They can stimulate the opening of K+ channels which brings the neuron closer to the equilibrium potential of K+, hyperpolarising the neuron. This prevents sodium channels from opening, action potentials from firing, and VDCCs from opening, and so stops neurotransmitter release. Thus GABAB receptors are considered inhibitory receptors.
GABAB receptors can also reduce the activity of adenylyl cyclase and decrease the cell’s conductance to Ca2+.
GABAB receptors are involved in behavioral actions of ethanol, gamma-Hydroxybutyric acid (GHB), and possibly in pain. Recent research suggests that these receptors may play an important developmental role.
Read more about this topic: GABAB Receptor
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