GABAA-rho Receptor - Function

Function

In addition to containing a GABA binding site, the GABA_A-ρ receptor complex conducts chloride ions across neuronal membranes. Binding of GABA to the receptor results in opening of this channel. When the reversal potential of chloride is less than the membrane potential, chloride ions flow down their electrochemical gradient into the cell. This influx of chloride ions lowers the membrane potential of (hyperpolarizes) the neuron, making it more difficult for these cells to conduct electrical impulses in the form of an action potential. Following stimulation by GABA, the chloride current produced by GABA_A-ρ receptors is slow to initiate but sustained in duration. In contrast, the GABA_A receptor current has a rapid onset and short duration. GABA is about 10 times more potent at GABA_A-ρ than it is at most GABA_A receptors.