Epidemiology and Disease Associations
Fundic gland polyps are found in 0.8 to 1.9% of patients who undergo esophagogastroduodenoscopy, and are more common in middle aged women.
The most important consideration in evaluating patients with fundic gland polyps is determining whether there is an underlying congenital cause for the condition, or whether the condition was acquired. This is to ascertain the risk of development of gastric cancer, and to ascertain the risk of concomitant colon cancer.
Fundic gland polyps can be found in association with the following genetic conditions :
- familial adenomatous polyposis
- attenuated familial adenomatous polyposis syndromes
The following are acquired causes for fundic gland polyps :
- chronic use of proton pump inhibitors (proposed by some authors, denied by others)
- Zollinger-Ellison syndrome
Helicobacter pylori infection does not correlate with fundic gland polyposis, and may cause polyp regression.
Read more about this topic: Fundic Gland Polyposis
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