Detoxification
The inhibition of ceramide synthase by FB1 is thought to be reversible, since the binding is formed by noncovalent interactions. Factors that will probably induce this reversibility are reduction of cellular FB1-concentration and increasing of cellular concentrations of the substrates for ceramide synthase. Also, the rate of removal of the accumulated sphinganine and sphingosine will affect the detoxification. The information on metabolism and biotransformation of FB1 is very sparse. However, metabolism most likely occurs in the gut since partially hydrolysed and fully hydrolysed FB1 were recovered in faeces but not in bile of Vervet monkeys. Bioavailability of FB1 can be reduced by treating fumonisin-contaminated corn with glucomannans extracted from the cell wall of the yeast Saccharomyces cerevisiae. These polysaccharides are able to bind certain mycotoxins and have a 67% binding capacity for fumonisins.
Read more about this topic: Fumonisin B1