The Fujimoto-Belleau reaction is a chemical reaction that forms cyclic α-substituted α,β-unsaturated ketones from enol lactones. The reaction is named after the two chemists George I. Fujimoto and Bernard Belleau.
The reaction is a Grignard reaction, followed by a H-shift, an enol-keto tautomerisation and an Aldol addition reaction. The last step is an elimination (Aldol condensation) reaction with an E1CB mechanism.
Famous quotes containing the word reaction:
“The excessive increase of anything often causes a reaction in the opposite direction.”
—Plato (c. 427–347 B.C.)