Limits
In all instances only esters can be used with stable acyl components that can withstand the harsh conditions of the Fries rearrangement. If the aromatic or the acyl component is heavily substituted then the chemical yield will drop due to steric constraints. Deactivating meta-directing groups on the benzene group will also have an adverse effect as can be expected for a Friedel–Crafts acylation.
Read more about this topic: Fries Rearrangement
Famous quotes containing the word limits:
“To the extent to which genius can be conjoined with a merely good human being, Haydn possessed genius. He never exceeds the limits that morality sets for the intellect; he only composes music which has “no past.””
—Friedrich Nietzsche (1844–1900)
“The great ship, Balayne, lay frozen in the sea.
The one-foot stars were couriers of its death
To the wild limits of its habitation.
These were not tepid stars of torpid places
But bravest at midnight and in lonely spaces,
They looked back at Hans’ look with savage faces.”
—Wallace Stevens (1879–1955)
“In a virtuous action, I properly am; in a virtuous act, I add to the world; I plant into deserts conquered from Chaos and Nothing, and see the darkness receding on the limits of the horizon.”
—Ralph Waldo Emerson (1803–1882)