Limits
In all instances only esters can be used with stable acyl components that can withstand the harsh conditions of the Fries rearrangement. If the aromatic or the acyl component is heavily substituted then the chemical yield will drop due to steric constraints. Deactivating meta-directing groups on the benzene group will also have an adverse effect as can be expected for a Friedel–Crafts acylation.
Read more about this topic: Fries Rearrangement
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—Milan Kundera (b. 1929)
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—Terri Apter (20th century)