Forensic Toxicology - Detection and Classification

Detection and Classification

Detection of drugs and pharmaceuticals in biological samples is usually done by an initial screening and then a confirmation of the compound(s), which may include a quantitation of the compound(s). The screening and confirmation are usually, but not necessarily, done with different analytical methods. Every analytical method used in forensic toxicology should be carefully tested by performing a validation of the method to ensure correct and indisputable results at all times. A testing laboratory involved in forensic toxicology should adhere to a quality programme to ensure the best possible results and safety of any individual.

The choice of method for testing is highly dependent on what kind of substance one expects to find and the material on which the testing is performed. Biological samples are more complex to analyze because of factors such as the matrix effect and the metabolism and conjugation of the target compounds.