Grading
According to the WHO criteria, the disease is morphologically graded into:
- grade 1 (<5 centroblasts per high-power field (hpf))
- grade 2 (6–15 centroblasts/hpf)
- grade 3 (>15 centroblasts/hpf).
Grade 3 is further subdivided into:
-
- grade 3A (centrocytes still present)
- grade 3B (the follicles consist almost entirely of centroblasts)
The clinical relevance of this grading system is still being debated; Grades 1, 2, and 3A are considered to be indolent and incurable, whereas grade 3B is considered an aggressive but curable disease similar to diffuse large B-cell lymphoma. Occasional cases may show plasmacytoid differentiation or foci of marginal zone or monocytoid B-cells.
Read more about this topic: Follicular Lymphoma
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