Early History
Some of the earliest work in Flux Balance Analysis dates back to the early 1980s. Papoutsakis demonstrated that is was possible to construct flux balance equations using a metabolic map. It was Watson however who first introduced the idea of using linear programming and an objective function to solve for the fluxes in a pathway. The first significant study was subsequently published by Fell and Small who used flux balance analysis together with more elaborate objective functions to study the constraints in fat synthesis.
Read more about this topic: Flux Balance Analysis
Famous quotes containing the words early and/or history:
“An early dew woos the half-opened flowers”
—Unknown. The Thousand and One Nights.
AWP. Anthology of World Poetry, An. Mark Van Doren, ed. (Rev. and enl. Ed., 1936)
“Books of natural history aim commonly to be hasty schedules, or inventories of God’s property, by some clerk. They do not in the least teach the divine view of nature, but the popular view, or rather the popular method of studying nature, and make haste to conduct the persevering pupil only into that dilemma where the professors always dwell.”
—Henry David Thoreau (1817–1862)