Buchwald Modification
Using palladium chemistry developed at MIT by Stephen Buchwald, the Fischer indole synthesis can be completed using aryl bromides as starting materials. Note that this also gives evidence to the fact that hydrazones are potential intermediates in the classical Fischer indole synthesis.
Methanesulfonic acid can be used as the acid catalyst in this reaction.
Read more about this topic: Fischer Indole Synthesis
Famous quotes containing the word buchwald:
“A bad liver is to a Frenchman what a nervous breakdown is to an American. Everyone has had one and everyone wants to talk about it.”
—Art Buchwald (b. 1925)