Treatment
The best treatment for Felty's syndrome is to control the underlying RA. Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly; this finding reflects the fact that Felty's syndrome is an immune-mediated disease. Most of the traditional medications used to treat RA have been used in the treatment of Felty's syndrome. No well-conducted, randomized, controlled trials support the use of any single agent. Most reports on treatment regimens involve small numbers of patients.
Splenectomy may improve neutropenia in severe disease.
Use of rituximab and leflunomide have been proposed.
Use of gold therapy has also been described.
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