Fecal Bacteriotherapy - History

History

The first description of FMT was published in 1958 outlining the successful treatment of four patients with pseudomembranous colitis before C. difficile was the known cause. Since that time sporadic cases have appeared in the literature.

At the CDD there were indications that FMT could benefit other conditions including ulcerative colitis, autoimmune disorders, neurological conditions, obesity, metabolic syndrome and diabetes, and Parkinson's disease. The future of FMT is likely to move away from crude, homogenised human flora and progress towards the use of highly refined stool, comprising bacteria only and mixed with a cryoprotectant to be frozen and stored for usage. Ultimately such an extract can be dried, powdered and encapsulated to be administered as an enteric coated medication for use in a number of flora-related conditions.

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